To compare the expression of p53 with hormonal receptor status in breast carcinoma: An immunohistochemical study

Background: Breast carcinoma is the most common malignancy in women world. This study evaluated expression of ER, PR and p53 breast its correlation with age, size, lymph node status other parameters. Methods: 103 histologically proven cases were subjected to IHC for ER,PR p53. Result: Total cancer 103. All between 21-60 years tumour size varying from 0.5->5cm. Maximum grade III. Metastatic carcinomatous deposits nodes seen 53 cases. Tumors separated into 4 categories depending on ER/PR ER-ve/PR-ve category having maximum number As increased lesser was ER expression. P53 positivity noted 60 comprising 58.3%. Significant while comparing lympho vascular invasion (p=0.042) but not status. also correlating (p = 0.036) grade, Conclusion: In present it observed that inversely proportional It concluded has direct relationship lymphovascular invasion. Thus helps provide prognostic information better treatment options